glutathione peroxidase and febrile seizure is there any correlation?

objective: to determine the relationship between serum glutathione peroxidase and febrile seizure. materials & methods:   in this case-control study, 43 children with simple febrile seizure (case group) were compared with 43 febrile children without seizure (control group) in terms of serum glutathione peroxidase level. serum glutathione peroxidase levels were measured by elisa method. the results were analyzed and compared in two groups. results:   from a total of 43 children 24 (53%) were male and 19 (47%) were female in children with simple febrile seizure, and 26 (60%) were male and 17 (40%) were female in febrile children without seizure (control group) (p=0.827). serum glutathione peroxidase level was 166±107u/ml in the case group and 141±90.5 u/ml in the control group (p=0.244). no significant difference was observed between the two groups in terms of serum glutathione peroxidase level. conclusion:   this study showed that there is no significant relationship between serum glutathione peroxidase and simple febrile seizure. thus, it seems that glutathione peroxidase, an essential component of antioxidant system, does not play any role in the pathogenesis of simple febrile seizure.